Florfenicol Injection 30% for Treatment of Bacterial Diseases in Cattle Sheep

• Varieties: Parasite Disease Prevention Medicine
• Component: Chemical Synthetic Drugs
• Type: The First Class
• Pharmacodynamic Influential Factors: Combined Medication
• Storage Method: Prevent High or LowTemperature
• Veterinary Reg. No.: (2018) Veterinary Drug Production Certificate No.
• Model NO.: Florfenicol Injection 30%
• Transport Package: Carton
• Specification: 100ml or Customized
• Trademark: CXBT
• Origin: Henan China
• Production Capacity: 50000bottle/Week

Product Description

Generic name:Florfenicol Injection 30%

Description: This product is a colorless to slightly yellow clear liquid.

Pharmacological Actions:Pharmacodynamics:

 Florfenicol is a broad-spectrum antibiotic of amide alcohols and is a bacteriostatic agent. It acts by binding to the 50S subunit of the ribosome to inhibit the synthesis of bacterial protein. It has strong antibacterial activity against a variety of Gram-positive bacteria and Gram-negative bacteria. Pasteurella hemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae are highly sensitive to florfenicol. The antibacterial activity of florfenicol against many microorganisms in vitro is similar to or stronger than that of thiamphenicol. Some bacteria resistant to amide alcohols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be resistant to fluorobenzene Nico is sensitive.

It is mainly used for the bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, such as the respiratory diseases of cattle and pigs caused by Pasteurella hemolyticus, Pasteurella multocida and Actinobacillus pleuropneumoniae. Salmonella caused by typhoid fever and paratyphoid fever, chicken cholera, chicken pullorum, colibacillosis, etc.; fish bacterial sepsis caused by fish pasteurella, vibrio, Staphylococcus aureus, hydrophila, enteritis, etc. Enteritis, red skin disease, etc.

Pharmacokinetics:  The oral administration of florfenicol is quickly absorbed, and the therapeutic concentration can be reached in the blood after about 1 hour, and the peak blood concentration can be reached within 1 to 3 hours. The bioavailability is over 80%. Florfenicol is widely distributed in animals and can penetrate the blood-brain barrier. It is mainly excreted in urine in its original form, and a small amount is excreted in feces.

Drug Interaction: 

(1) Macrolides and Lincosamides have the same target of action as this product, both of which are combined with the 50S subunit of the bacterial ribosome, which can produce mutual antagonism when used in combination.
(2) It may antagonize the bactericidal activity of penicillins or aminoglycoside drugs, but it has not been proven in animals.

Function and Use: Amido alcohol antibiotics. Used for bacterial diseases caused by Pasteurella and Escherichia coli. 
Dosage and Administration:

For subcutaneous or intramuscular injection.
Cattle:
Treatment (IM) : 1 ml per 15 kg body weight, twice at a 48-h interval.
Treatment (SC) : 2 ml per 15 kg body weight, administered once.
Prevention (SC) : 2 ml per 15 kg body weight, administered once.
The injection should only be given in the neck. The dose should not exceed 10 ml per injection site.
Swine : 1 ml per 20 kg body weight (IM), twice at a 48-hour interval.
The injection should only be given in the neck. The dose should not exceed 3 ml per injection site.
It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours after the second injection. If clinical signs of respiratory disease persist 48 hours after the last injection, treatment should be changed using another formulation or another antibiotic and continued until clinical signs have resolved. Note: Introflor-300 is not for use in cattle producing milk for human consumption.

Adverse Reactions:

(1) This product has a certain immunosuppressive effect when used higher than the recommended dose.
(2) It has embryo toxicity, and it should be used with caution for livestock during pregnancy and lactation.

Precautions:

(1) Banned during laying hens.
(2) Animals with severely impaired immune function during the vaccination period are prohibited.
(3) Animals with renal insufficiency need to appropriately reduce the dose or extend the interval between administrations.

Withdrawal Period: 20 days for pigs, 5 days for chickens, and 375 degree days for fish.

Specification: 30%.

Packing: 100ml/bottle.

Storage: Sealed and stored in a dry place.

Henan Chuangxin Biological Technology Co., Ltd. is a large joint-stock company integrating animal drug research and
development, production and sales, and after-sales service. In December 2012, the one-time high score passed the
acceptance of eight veterinary drug GMP production lines of the Ministry of Agriculture. The production dosage forms
involve powder/premix, terminally sterilized small-volume injection (including Chinese medicine extraction)/terminally
sterilized large-volume non- Intravenous injection (including traditional Chinese medicine extraction) / oral liquid solution
(including traditional Chinese medicine extraction), non-chlorine disinfectant (liquid), feed additives(Probiotics Green) and
Originally created China's leading Chinese medicine antiviral preparations, animal Chinese medicine extract preparations
such as Toad venom and Cantharidin. Known as the GMP standard model factory of veterinary drugs in Henan Province.