| Varieties: | Parasite Disease Prevention Medicine |
|---|---|
| Component: | Chemical Synthetic Drugs |
| Type: | The First Class |
| Pharmacodynamic Influential Factors: | Repeated Medication |
| Storage Method: | Prevent High or LowTemperature |
| Veterinary Reg. No.: | (2018) Veterinary Drug Production Certificate No. |
| Samples: |
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| Customization: |
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| Composition | Dexamethasone 1 mg Benzyl alcohol (E1519) …. 10 mg Excipient QSP 1 ml |
| Cons-indications | Don′t use in animals suffering from diabetes mellitus, hyperadrenocorticism, renal insufficiency and heart failure or suffering from peptic ulcers. Don′t use in animals with infectious disease, unless appropriate anti-infectious therapy is administered at the same time. |
| I) Special precautions for use in animals |
Administration of corticosteroids at the end of pregnancy may result in premature delivery or abortion in ruminants. Except in the indications of acetonaemia and induction of parturition, the function of corticosteroids is to improve rather than cure. Therefore, it′s advisable to diagnose and treat the underlying disease. When used to treat shock, intravenous fluids should be administered to maintain circulation; An acid-base assessment must be carried out. |
| Undesirable effects (frequency and severity) | In prolonged use, corticosteroids such as dexamethasone may cause iatrogenic hypercorticism, polyuropolydipsia (PUPD), immunosuppression, bulimia and redistribution of the body's lipid reserves. The use of corticosteroids in lactating cattle and goats may lead to a temporary decline in milk production. Induction of parturition with corticosteroids may be associated with reduced progeny viability and increased incidence of placental retention. |
| Drug Interactions and Other Forms of Interaction |
Acts on several systems of the animal and the result is a remarkable increase in the performance Because corticosteroids can reduce the immune response to vaccination, dexamethasone should not be given at the same time as vaccines. Concomitant use of non-steroidal anti-inflammatory drugs may increase the risk of ulceration of the gastrointestinal tract. |
| Dosage and route of administration all species | Intravenous or intramuscular use. Equine, Camel, cattle, goats, pigs 0.04 to 0.10 mg / kg (4 to 10 ml / 100 kg) Dogs, cats 0.05 to 0.10 mg / kg (0.5 to 1 ml / 10 kg) Dosification & Administration for Race : For professional application not detected, read the article about dexa for race: Click Here For safe application not detected pre-race: 5 ml for 5 days, suspend 2 days before the race Overdose (symptoms, emergency management, antidotes), if necessary High doses of corticosteroids may cause somnolence and lethargy in equines. |
| Waiting time | Meat and offal: 6 days. Milk: 3 days. |
| Pharmacological Properties | Dexamethasone is a potent synthetic glucocorticoid with low mineralocorticoid activity. Dexamethasone has ten to twenty times the anti-inflammatory activity of prednisolone at an equivalent molar dose. Corticosteroids may decrease the immune response. Indeed, they inhibit capillary dilation, leukocyte migration and phagocytosis. Glucocorticoids have an effect on metabolism by increasing gluconeogenesis. Dexamethasone induces parturition in ruminants if the fetus is alive. After administration of the product intramuscularly, dexamethasone is absorbed rapidly, resulting in a rapid and short-acting response. T max in cattle, goats, horses, pigs, dogs and cats is reached within 30 minutes after intramuscular administration. The T? (half-life time) varies depending on the species between 5 and 20 hours. The bioavailability after intramuscular administration is approximately 100%. |
Henan Chuangxin Biological Technology Co., Ltd. is a large joint-stock company integrating animal drug research and
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